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Application of magnesium sulfate in obstetrics
Dec 03, 2018

The use of magnesium sulfate during pregnancy in accordance with routine dosage and course of treatment is of low risk to fetal bones, so there is no need to worry too much. Magnesium sulfate is often used in the process of hot flashes, sweating, dry mouth, nausea, vomiting, injection site pain, suffocation, chest tightness, limb pain numbness and other discomforts. As an antispasmodic, it can be used to prevent and control convulsions in patients with pregnancy-induced hypertension, preeclampsia and eclampsia, and as a neuroprotective agent for fetal brain, it can be used in patients who may be premature before 32 weeks to reduce the risk of cerebral palsy in premature infants. Prolonging gestational age can help patients who may have premature delivery within 7 days to gain time for drug-induced fetal lung maturation. 

The course of treatment is different for different purposes. For one purpose, the course of treatment is usually 5-7 days, intermittent repeated treatment when necessary, and the use of magnesium sulfate for 24-48 hours after delivery is generally recommended. 

For two or three purposes, the current guidelines for preterm birth treatment at home and abroad generally recommend a course of 48 hours. If the concentration of magnesium ion is within a reasonable range and the patient can tolerate it, the drip rate can be slowed down to continue treatment; if the magnesium ion is within a reasonable range and the patient can not tolerate or suffer from toxic symptoms such as knee tendon reflex disappearance, respiratory frequency and urine volume reduction, it can be used. If the concentration of magnesium ion exceeds the poisoning concentration, the drug should be stopped immediately and calcium gluconate should be actively used for rescue and symptomatic treatment.

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